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Tracheal Allotransplantation

Pierre Delaere, MD, PhD, Tony Lerut, MD, FRCS, Dirk Van Raemdonck, MD, PhD
Tracheal Allotransplantation is a topic covered in the Pearson's General Thoracic.

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Keypoints

  • Orthotopic tracheal transplantation is possible after heterotopic revascularization.
  • Forearm provides a suitable and reliable revascularization site.
  • Immunosuppressive drugs are necessary for tracheal allograft revascularization.
  • Intercartilaginous incisions need to be made between every two cartilage rings and buccal mucosa grafts need to be introduced before immunosuppressive drugs can be safely withdrawn.
  • Chondrocytes are immunologically privileged because they are protected within a matrix.
  • Vascularized tissue covering the mucosal site of the allograft after forearm implantation may accelerate processes of revascularization and donor mucosal regeneration.
  • Tracheal allotransplantation has proven successful for the repair of long-segment stenosis.

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Keypoints

  • Orthotopic tracheal transplantation is possible after heterotopic revascularization.
  • Forearm provides a suitable and reliable revascularization site.
  • Immunosuppressive drugs are necessary for tracheal allograft revascularization.
  • Intercartilaginous incisions need to be made between every two cartilage rings and buccal mucosa grafts need to be introduced before immunosuppressive drugs can be safely withdrawn.
  • Chondrocytes are immunologically privileged because they are protected within a matrix.
  • Vascularized tissue covering the mucosal site of the allograft after forearm implantation may accelerate processes of revascularization and donor mucosal regeneration.
  • Tracheal allotransplantation has proven successful for the repair of long-segment stenosis.

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Last updated: October 31, 2019