Induction and Adjuvant Therapy for Cancer of the Esophagus
Key Points
- Multimodality therapy is an important component of curative-intent treatment of cancer of the esophagus. The evidence on the optimal preoperative management is controversial, with some authors advocating for neoadjuvant chemotherapy or perioperative chemotherapy and others advocating for concurrent chemotherapy and radiation therapy (CRT).
- There are compelling data that neoadjuvant CRT followed by surgery has a survival benefit compared with surgery alone for patients with locally advanced and/or node positive disease.
- There is level one evidence that adjuvant immunotherapy use following treatment with CRT for patients with non pathologic complete response improved disease free survival (DFS), whether this will translate into an overall survival benefit has yet to be determined.
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Last updated: December 19, 2022
Citation
Lukovic, Jelena, et al. "Induction and Adjuvant Therapy for Cancer of the Esophagus." Pearson's General Thoracic Surgery. STS Cardiothoracic Surgery E-Book, Chicago: Society of Thoracic Surgeons, 2022. STS Surgery, ebook.sts.org.
Lukovic J, Elimova E, Yeung J. Induction and Adjuvant Therapy for Cancer of the Esophagus. In: Darling GE, Baumgartner WA, Jacobs JP, eds. Pearson's General Thoracic Surgery. STS Cardiothoracic Surgery E-Book. Chicago: Society of Thoracic Surgeons; 2022. ebook.sts.org. Accessed September 27, 2023.
Lukovic, J., Elimova, E., & Yeung, J. (2022). Induction and Adjuvant Therapy for Cancer of the Esophagus. In Darling, G., Baumgartner, W., & Jacobs, J. (Eds.), Pearson's General Thoracic Surgery. STS Cardiothoracic Surgery E-Book. Chicago: Society of Thoracic Surgeons. ebook.sts.org
Lukovic J, Elimova E, Yeung J. Induction and Adjuvant Therapy for Cancer of the Esophagus [Internet]. In: Darling GE, Baumgartner WA, Jacobs JP, editors. Pearson's General Thoracic Surgery. STS Cardiothoracic Surgery E-Book. Chicago: Society of Thoracic Surgeons; 2022. [cited 2023 September 27]. Available from: ebook.sts.org.
* Article titles in AMA citation format should be in sentence-case
TY - ELEC
T1 - Induction and Adjuvant Therapy for Cancer of the Esophagus
ID - 1418552
A1 - Lukovic,Jelena,
AU - Elimova,Elena,
AU - Yeung,Jonathan,
ED - Jacobs,J,
ED - Darling,Gail,
ED - Baumgartner,William,
Y1 - 2022/12/19/
BT - Pearson's General Thoracic
UR - https://ebook.sts.org/sts/view/Pearsons-General-Thoracic/1418552/all/Induction_and_Adjuvant_Therapy_for_Cancer_of_the_Esophagus
PB - Chicago: Society of Thoracic Surgeons
DB - STS Surgery
DP - Unbound Medicine
ER -