Key Points

• Emerging technologies may allow for more widespread screening of Barrett’s esophagus in high-risk individuals.
• Keystone of medical therapy is acid suppression with proton pump inhibition.
• Following diagnosis, interval surveillance endoscopy is performed to detect dysplasia and early adenocarcinoma with new technologies and devices allowing for better risk stratification.
• Staging of early adenocarcinoma with endoscopic ultrasound (nodal involvement) and endoscopic resection (T classification) determines if a patient is a candidate for endoscopic therapy.
• Endoscopic therapy includes endoscopic resection, cryotherapy and radiofrequency ablation for dysplasia and early adenocarcinoma.