Induction and Adjuvant Therapy for Operable Non-Small Cell Lung Cancer
Key Points
- Chemotherapy given prior to surgery has been shown to improve survival in both early-stage and locally advanced non-small-cell lung cancer (NSCLC), although typically induction chemotherapy is recommended for only locally advanced NSCLC
- There are no significant differences in survival between patients undergoing induction chemotherapy and induction chemoradiation for N2 NSCLC
- Chemotherapy given after surgery for N1 and N2 NSCLC has been shown to improve survival. Adjuvant chemotherapy should also be considered for patients with stage IB disease with high-risk factorsT
- Adjuvant radiation is not currently recommended for early-stage NSCLC that has been completely resected. Adjuvant radiation may be considered in select cases of stage IIIA after discussion in a multidisciplinary setting. Radiation can be considered after surgery for R1 and R2 resection
- Several new randomized trials are evaluating the efficacy of molecularly targeted agents and immunotherapy in the induction and adjuvant setting
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Last updated: January 3, 2020
Citation
Yang, Chi-Fu J, et al. "Induction and Adjuvant Therapy for Operable Non-Small Cell Lung Cancer." Pearson's General Thoracic Surgery. STS Cardiothoracic Surgery E-Book, Chicago: Society of Thoracic Surgeons, 2020. STS Surgery, ebook.sts.org.
Yang CJ, Shah S, D’Amico T. Induction and Adjuvant Therapy for Operable Non-Small Cell Lung Cancer. In: Darling GE, Baumgartner WA, Jacobs JP, eds. Pearson's General Thoracic Surgery. STS Cardiothoracic Surgery E-Book. Chicago: Society of Thoracic Surgeons; 2020. ebook.sts.org. Accessed September 23, 2023.
Yang, C. J., Shah, S., & D’Amico, T. (2020). Induction and Adjuvant Therapy for Operable Non-Small Cell Lung Cancer. In Darling, G., Baumgartner, W., & Jacobs, J. (Eds.), Pearson's General Thoracic Surgery. STS Cardiothoracic Surgery E-Book. Chicago: Society of Thoracic Surgeons. ebook.sts.org
Yang CJ, Shah S, D’Amico T. Induction and Adjuvant Therapy for Operable Non-Small Cell Lung Cancer [Internet]. In: Darling GE, Baumgartner WA, Jacobs JP, editors. Pearson's General Thoracic Surgery. STS Cardiothoracic Surgery E-Book. Chicago: Society of Thoracic Surgeons; 2020. [cited 2023 September 23]. Available from: ebook.sts.org.
* Article titles in AMA citation format should be in sentence-case
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T1 - Induction and Adjuvant Therapy for Operable Non-Small Cell Lung Cancer
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ED - Baumgartner,William,
Y1 - 2020/01/03/
BT - Pearson's General Thoracic
UR - https://ebook.sts.org/sts/view/Pearsons-General-Thoracic/1418467/all/Induction_and_Adjuvant_Therapy_for_Operable_Non_Small_Cell_Lung_Cancer
PB - Chicago: Society of Thoracic Surgeons
DB - STS Surgery
DP - Unbound Medicine
ER -