Adenocarcinoma of the gastroesophageal junction includes tumors of the distal esophagus or gastric cardia that involve the gastroesophageal junction wherein the epicenter of the tumor is within 5 cm above or below the gastroesophageal junction. The major risk factors for this cancer include obesity and gastroesophageal reflux. Lymphatic metastases include abdominal nodes similar to gastric cancers and mediastinal lymph nodes similar to esophageal cancers. Most tumors are locally advanced at the time of detection and recommended treatment include preoperative chemotherapy or chemoradiation followed by surgery with radical lymphadenectomy.
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